Rotavirus-A contagious virus

TRANSMISSION

Rotavirus transmits the disease through fecal matter, and person to person through close contacts. Some of the viruses strains need a host to get transmit, after the productionvirus protein produced by the host, and it leads to destroy the host cell to decrease the immunity. The pathogen can transmit from one place to another and infected the whole area of hospitals with the help of various objects. The report suggests that researchers have assumed rotavirus is an airborne disease that is getting transmitted to infect the healthy person, and they
are trying to produce the more effective vaccines which can produce the antibody in our body.

Mechanism of Rotavirus Replication
Rotavirus initiates replication process in top and middle villi of small intestine via non – dividing enterocytes. Enteroendocrine cells and mature enterocytes susceptibility towards rotavirus infection was shown in mice and HIE (Human Intestinal Enteroid) cultures. Outer capsid proteins along with host cell surface molecules like HBGA (Histo blood group antigens) and sialoglycans; mediate the attachment of rotavirus to host cellSanderson C et al., (2011) states that rotavirus needs more expression factors for replicating, infecting, and destroying the host cells. Groome, M. J. et al., observed that human enteroendocrine cell linein mice (transformed version) are responsible for the infection in the mature enteroendocrine and enterocytes cells. Rotavirus will be attached to the surface of the
enterocyte microvilli of the small intestine cell and binds to the host cell with the help of a receptor. The outer capsid proteinVP4 (through its VP8* domain) binds to the surface of the host cell (gangliosides GM1 and GD1a) and HBGAs (Histo-blood group antigens). In Africa, rotavirus infection in children is caused by the Lewis-negative glycan phenotype. HBGA expression contains genetic changes, which shows distinct changes in rotavirus genotypes
because of enriching regulated precursor HBGA, and the high prevalence of P genotype. The Rotavirus vaccine strain is the vulnerable in nature and the vaccine efficacy. Rotavirus is capable for the producing multiple copies of itself in the cytoplasm and leaving the host cell after damaging through cell lysis.