Rotavirus-A contagious virus

INTRODUCTION
Rotavirus belongs from the family of Reoviridae and contains 11 segments of dsRNAs that are enveloped by the complex architecture of three concentric capsids. It has six structural proteins and six non – structural proteins encoded by RNA segments which are covering the dsRNAs. The mature virus contains a protein that regulates the cell entry, enzymatic functions and specificity, which are useful for generation of viral transcript and initiation of immune response. Replication of genome and innate immune response are induced by the non-structural protein
(NSP4 main role). Mainly, 10 species of rotavirus have considered based upon the sequence. In infants, the most common infecting disease is affected by rotavirus species A which hasVP7 & VP4 segments that contains various types of genotypes that are based on the length of the sequence. VP7 (Rotavirus A species) has dual nature of nomenclature that represents the glycoprotein and VP4 protein subtypes. Banafild WG states that the six G
type strains and 3 P-type strains of Rotavirus has been observed. Globally, rotavirus is a severe disease, and the virus infectacute gastroenteritis, mostly in case of infants, young children, and also life-sinister throughout the world. According to the studies, poor countries are affected by more than 5 lakh death rates all over the world.