Coronavirus disease (COVID-19) outbreak

Possible prophylaxis enactment (SARS-CoV-2)

Most of the health workers and doctors are exposed to COVID-19 across the world. The current available prophylactic enactment is very constrained to rebate the infected peoples. So, in case of medication prophylaxis, vaccinations are important to excursion places where many diseases are endemic such as chloroquine treatment is initiated prophylactically a week before going to excursion areas where malaria is very prevalent. And nowadays anti-retroviral therapies are also coming in used prophylactically to cure the disease at liability to reduce HIV.

In case of Chloroquine & hydroxychloroquine as pre-exposure prophylaxis in contrast to SARS-CoV-19 by Yao et al. Hydroxychloroquine was more impressive and effective than chloroquine in reaching half of the effective concentration (EC₅₀). According to clinical trials of hydroxychloroquine and chloroquine, a study highlighted that use of high dosage leads to higher cellular accumulation & drown out the half life cycle. Based on all in-vitro studies, researchers have arbitrated the prophylactic use of hydroxychloroquine and chloroquine on contrary to COVID-19.

However, the main objective of the prophylaxis is eluded if a drug will be used without knowing the scientific proofs or analysis, it leads to major hysteria like patients with arthritis, for utilizing these drugs.

The above table shows the commercially accessible medicines used for the treatment of the many types of coronaviruses and the viral disease discussed in the above table indulges the SARS, RSV, MERS, ARVI & COVID-19.

• SARS- – Severe Acute Respiratory Syndrome
• RSV – Respiratory Syncytial Virus
• MERS – Middle East Respiratory Syndrome
• ARVI – Acute respiratory viral infections.
• Coronavirus disease